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You may have enjoyed the 10-OH-HHC among our new products, but today we're talking about its cousin, the 8-OH-HHC!
Although these two metabolites are very close to each other at the molecular level, 8-OH-HHC has a unique level of interaction that enables it to develop its own specificities and distinct effects.
Want to learn more about 8-Hydroxyhexahydrocannabinol? We've got you covered with this new CBD-derived nugget that's about to take the market by storm.
8-oh hhc is a metabolite, i.e. a by-product created by the body's "digestion" of HHC.
When HHC is consumed, it enters the bloodstream before being filtered and processed by the liver and its enzymes. Following treatment by the various enzymes, a series of oxygenated by-products are created. Some of these by-products retain biological and psychoactive activity, as in the case of the two that interest us here, 10-OH-HHC and 8-OH-HHC.
But these are far from being the only metabolites created by HHC consumption. We don't know exactly how many are created, but as HHC is processed like thc in many respects, we consider that it could create a roughly equivalent number, i.e. around 80 different metabolites.
Some preliminary studies, such as those carried out by Professor Mechoulam when he discovered HHC metabolites in the 1940s, showed that 8-OH-HHC could have psychoactive effects similar to those of HHC. These effects are themselves quite similar to those of Delta 9 THC.
According to the results of these studies, it seems that 8-oh-hhc can generate interactions with CB1 and CB2 receptors, causing :
As you can see, given its effects, 8-OH-HHC could be a perfect candidate if you're looking for a legal alternative to HHC and HHC-Po, which are now banned.
As already mentioned, there are many similarities between 8 oh HHC and 10 oh hhc. At the molecular level, the difference is quite slight, but they are distinguished by the position of their hydroxyl groups (OH). The OH group is located in the 8th position of the carbon chain for 8 oh and in the 10th position for 10 oh hhc.
In terms of effects,both molecules are quite similar to HHC. They are both capable of psychoactive effects and a similar high. But the psychoactive effect of 10-oh-hhc tends to be shorter, whereas 8-oh-hhc is longer but milder.
Another difference between the two is that 10 oh HHC has been found in very small quantities in some cannabis flowers. This is not the case for 8 OH, which has never been found in anything other than human or animal secretions.
Although known since the 1940s, to date there is very little reliable, solid scientific data on 8 oh HHC. The compound has not yet been the subject of in-depth, exhaustive studies. However, the limited data we have on 10 OH HHC and the much more extensive data on Delta 9 THC metabolites may shed some light on the potential medical uses of 8 OH HHC.
Most cannabinoids are known and widely studied for their pain-relieving potential, particularly for chronic pain, their anti-inflammatory and neuroprotective potential.
It's very possible that, because of its interaction with CB1 receptors, which play a key role in pain management, the treatment of inflammation and certain neurodegenerative diseases, 8-OH-HHC could find medical application in these areas. For the moment, however, there is no evidence to confirm or refute these suppositions.
In France, HHC and its derivatives such as HHCO, HHCP and HHCPO have been banned. But 8-oh-hhc and other hhc metabolites are recent discoveries, and have only just entered the CBD market. For the time being, these molecules are not specifically regulated, so they are legal as long as they contain less than 0.3% THC.
In the European Union, only France, Austria, Estonia, Poland, Sweden and Hungary have banned HHC and its derivatives. For the moment, however, no country has taken a position on 8-OH-HHC and 10-oh-hhc.
HHC metabolites have been studied with a view to their use in testing and screening. Indeed, as they are by-products of consumption, they are the ones sought as evidence of HHC consumption.
8-OH-HHC is the metabolite most strongly and rapidly represented in saliva when HHC is consumed. Tests reacting to this molecule could be set up, but as HHC is simply banned, such tests have not been developed.
Nevertheless, 8-Oh-HHC flowers and resins are like all other CBD products: they can contain up to 0.3% THC, which gives a positive result on the road test and could get you into trouble if you smoke them before driving.
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